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Friday, Apr.19, 2024
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| miRNA: |
hsa-miR-146a |
| Disease: |
papillary thyroid carcinoma (PTC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
KIT |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Up-regulation of several miRs (miR-221, -222, and -146) and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation. |
Reference:
The role of microRNA genes in papillary thyroid carcinoma. | PMID:16365291
He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la Chapelle A.
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80. Epub 2005 Dec 19. |
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