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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-148a |
| Disease: |
breast cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Aberrant hypermethylation leads to miRNA gene inactivation in human breast cancer. Aberrant hypermethylation was shown for mir-9-1, mir-124a-3, mir-148, mir-152, and mir-663 in 34-86% of cases in a series of 71 primary human breast cancer specimens.miRNA gene hypermethylation correlated strongly with methylation of known tumour suppressor genes (p = 0.003). |
Reference:
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. | PMID:17948228
Lehmann U, Hasemeier B, Christgen M, Muller M, Romermann D, Langer F, Kreipe H.
J Pathol. 2008 Jan;214(1):17-24. |
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