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Friday, May.3, 2024
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| miRNA: |
hsa-miR-18a |
| Disease: |
lung cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: frequent and marked overexpression, with occasional gene amplification, of clustered miRNAs (miR-17-92) within intron 3 of the C13orf 25 gene at 13q31.3 in lung cancers, especially examples with small-cell lung cancer histology.The authors further showed the stimulatory activity of this miRNA cluster in lung cancer cell growth. |
Reference:
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. | PMID:16266980
Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T.
Cancer Res. 2005 Nov 1;65(21):9628-32. |
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