miRNA: |
hsa-miR-193a |
Disease: |
Oral Squamous Cell Carcinoma (OSCC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
E2F6 |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: the ectopic transfection of miR-137 or miR-193a into OSCC lines lacking their expressions significantly
reduced cell growth, with down-regulation of the translation of cyclin-dependent kinase 6 or E2F transcription factor
6, respectively. Taken together, our results clearly show that miR-137 and miR-193a are tumor suppressor miRNAs epigenetically
silenced during oral carcinogenesis. |
Reference:
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. | PMID:18381414
Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J.
Cancer Res. 2008 Apr 1;68(7):2094-105. |
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