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Saturday, May.18, 2024
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| miRNA: |
hsa-miR-133a |
| Disease: |
cardiac hypertrophy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
HCN2, HCN4 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Down-regulation of miR-1 and miR-133 expression contributes to re-expression of HCN2/HCN4 thereby the electrical remodeling process in hypertrophic hearts. |
Reference:
Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. | PMID:18458081
Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y, Yang B, Wang Z.
J Biol Chem. 2008 Jul 18;283(29):20045-52. Epub 2008 May 5. |
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