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Sunday, May.19, 2024
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| miRNA: |
hsa-miR-133a |
| Disease: |
cardiomyopathy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
ERG |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Depression of key K+ channel(Ikr) via repression of ERG by miR-133 may contribute to the slowing of myocyte repolarization, and thereby QT prolongation and the associated arrhythmias in diabetic hearts |
Reference:
MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. | PMID:17344217
Xiao J, Luo X, Lin H, Zhang Y, Lu Y, Wang N, Zhang Y, Yang B, Wang Z.
J Biol Chem. 2007 Apr 27;282(17):12363-7. Epub 2007 Mar 7. |
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