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Tuesday, Apr.23, 2024
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| miRNA: |
hsa-miR-106b |
| Disease: |
multiple myeloma (MM) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PCAF |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We have confirmed that the proapoptotic BIM is a target of the miR-17-92 cluster in MM cells. Therefore, miR-17-92, along with miR-21, blocks apoptosis and promotes cell survival. On the other hand, miR-106b-25, miR-181a, and miR-32 but not miR-17-92 cluster (specifically miR-19s and miR-92), target PCAF, a p53 positive regulator. We speculate, consistent with the low frequency of p53 mutations in MM, that down-regulation of PCAF by the miR-106b-25 cluster, miR-181s, and miR-32, keeps p53 at low level or partially inactivated by controlling its stability through Hdm2 and working as a histone acetyltransferase. |
Reference:
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. | PMID:18728182
Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP,
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. Epub 2008 Aug 26. |
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