hsa-miR-126

acute myeloid leukemia (AML)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

PLK2

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Our gain- and loss-of-function experiments showed that miR-126/126* inhibited apoptosis and increased the viability of AML cells and enhanced the colony-forming ability of mouse normal bone marrow progenitor cells alone and particularly, in cooperation with AML1-ETO, likely through targeting Polo-like kinase 2 (PLK2), a tumor suppressor. A significantly negative effect on luciferase activity was observed in the presence of miR-126 on the 3 UTR of PLK2. These results indicate that PLK2 is a bona fide target of miR-126.

Reference:

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. | PMID:18832181
Li Z, Lu J, Sun M, Mi S, Zhang H, Luo RT, Chen P, Wang Y, Yan M, Qian Z, Neilly MB, Jin J, Zhang Y, Bohlander SK, Zhang DE, Larson RA, Le Beau MM, Thirman MJ, Golub TR, Rowley JD, Chen J.
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15535-40. Epub 2008 Oct 1.