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Friday, May.17, 2024
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| miRNA: |
hsa-miR-145 |
| Disease: |
colorectal cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
FLJ21308 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-145 showing the lowest expression in cancer relative to normal tissue. Functional studies showed that miR-145 potently suppressed growth of
three different colon carcinoma cell lines. Our data indicate that altered expression levels of miRNA-145 in colon cancer has a functional effect on transformed cells, and that miR-145 may act as a potent suppressor of tumor growth through an increased rate of cell death. |
Reference:
Diagnostic and prognostic microRNAs in stage II colon cancer. | PMID:18676867
Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskj?t L, Wiuf C, S?rensen FJ, Kruh?ffer M, Laurberg S, Kauppinen S, ?rntoft TF, Andersen CL.
Cancer Res. 2008 Aug 1;68(15):6416-24. |
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