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Wednesday, May.1, 2024
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| miRNA: |
hsa-miR-181a |
| Disease: |
multiple myeloma (MM) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
PCAF |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Xenograft studies using human MM cell lines treated with miR-19a and b, and miR-181a and b antagonists resulted in significant suppression of tumor growth in nude mice. |
Reference:
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. | PMID:18728182
Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP,
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12885-90. Epub 2008 Aug 26. |
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