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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-133b |
| Disease: |
Parkinson's disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
Pitx3 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-133b regulates the maturation and function of midbrain DNs within a negative feedback circuit that includes the paired-like homeodomain transcription factor Pitx3 |
Reference:
A MicroRNA feedback circuit in midbrain dopamine neurons. | PMID:17761882
Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A.
Science. 2007 Aug 31;317(5842):1220-4. |
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