Description: hsa-mir-21 (miR-21), was quantitatively analyzed by TaqMan real-time PCR in 113 BC tumors. Interestingly, among the 113 BC cases, high level expression of miR-21 was significantly correlated with advanced clinical stage (P=0.006, Fisher's exact text), lymph node metastasis (P=0.007, Fisher's exact text), and shortened survival of the patients (hazard ratio [HR]=5.476, P<0.001). Multivariate Cox regression analysis revealed this prognostic impact (HR=4.133, P=0.001) to be independent of disease stage (HR=2.226, P=0.013) and histological grade (HR=3.681, P=0.033). This study could identify the differentiated miRNAs expression profile in BC and reveal that miR-21 overexpression was correlated with specific breast cancer biopathologic features, such as advanced tumor stage, lymph node metastasis, and poor survival of the patients, indicating that miR-21 may serve as a molecular prognostic marker for BC and disease progression.
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