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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-21 |
Disease: |
glioblastoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
TGF-beta, HNRPK, TAp63 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: In this study, we show for the first time that miR-21 targets multiple important components of the p53, transforming growth factor-beta (TGF-beta), and mitochondrial apoptosis tumor-suppressive pathways. Down-regulation of miR-21 in glioblastoma cells leads to derepression of these pathways, causing repression of growth, increased apoptosis, and cell cycle arrest. These phenotypes are dependent on two of the miR-21 targets validated in this study, HNRPK and TAp63. These findings establish miR-21 as an important oncogene that targets a network of p53, TGF-beta, and mitochondrial apoptosis tumor suppressor genes in glioblastoma cells.
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Reference:
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. | PMID:18829576
Papagiannakopoulos T, Shapiro A, Kosik KS.
Cancer Res. 2008 Oct 1;68(19):8164-72. |
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