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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-210 |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Supervised analysis in the initial subset and subsequent analysis in additional tumors significantly linked four miRNAs (miR-7, miR-128a, miR-210, and miR-516-3p) to ER(+)/LNN breast cancer aggressiveness (n=147) and one miRNA (miR-210) to metastatic capability in ER(-)/LNN breast cancer ( n=114) and in the clinically important triple-negative subgroup (n=69) (all P<0.05). Bioinformatic analysis coupled miR-210 to hypoxia/VEGF signaling, miR-7 and miR-516-3p to cell cycle progression and chromosomal instability, and miR-128a to cytokine signaling. In conclusion, our work connects four miRNAs to breast cancer progression and to several distinct biological processes involved therein.
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Reference:
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer.
| PMID:18755890
Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, Boersma AW,
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13021-6. Epub 2008 Aug 28. |
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