hsa-miR-30d

Glomerulosclerosis

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Among 15 upregulated target genes of the mir-30 miRNA, four genes known to be expressed and/or functional in podocytes were identified, including receptor for advanced glycation end product, vimentin, heat-shock protein 20, and immediate early response 3. Receptor for advanced glycation end product and immediate early response 3 are known to mediate podocyte apoptosis, whereas vimentin and heat-shock protein-20 are involved in cytoskeletal structure. Taken together, these results provide a knowledge base for ongoing investigations to validate functional roles for the mir-30 miRNA family in podocyte homeostasis and podocytopathies. In conclusion, our results demonstrate that miRNA are important genomic regulators of molecular podocyte homeostasis. Disruption of miRNA-controlled gene networks results in progressive proteinuria and glomerulosclerosis.

Reference:

Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis. | PMID:18776119
Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP.
J Am Soc Nephrol. 2008 Sep 5. [Epub ahead of print]