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Friday, Mar.29, 2024
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miRNA: |
hsa-miR-34a |
Disease: |
chronic lymphocytic leukemia (CLL) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
E2F3 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Here, we show for the first time that microRNA-34a is significantly downregulated in CLL patients with TP53 deletions compared with CLL patients without such deletions. In these cases, we were not able to reveal BCL2 as a target of microRNA-34a. Still, BCL2 being only one of the microRNA-34a targets, a
potential function of a regulatory circuit involving the important tumor suppressor TP53 and microRNA-34a in the pathogenesis of CLL cannot be excluded, and needs to be further investigated. |
Reference:
17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. | PMID:18818704
Dijkstra MK, van Lom K, Tielemans D, Elstrodt F, Langerak AW, van 't Veer MB, Jongen-Lavrencic M.
Leukemia. 2008 Sep 25. [Epub ahead of print] |
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