Friday, Mar.29, 2024
miRNA:

hsa-miR-34a

Disease:

chronic lymphocytic leukemia (CLL)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

E2F3 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Here, we show for the first time that microRNA-34a is significantly downregulated in CLL patients with TP53 deletions compared with CLL patients without such deletions. In these cases, we were not able to reveal BCL2 as a target of microRNA-34a. Still, BCL2 being only one of the microRNA-34a targets, a potential function of a regulatory circuit involving the important tumor suppressor TP53 and microRNA-34a in the pathogenesis of CLL cannot be excluded, and needs to be further investigated.

 

 

Reference:

17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. | PMID:18818704
Dijkstra MK, van Lom K, Tielemans D, Elstrodt F, Langerak AW, van 't Veer MB, Jongen-Lavrencic M.
Leukemia. 2008 Sep 25. [Epub ahead of print]

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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