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Friday, May.17, 2024
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| miRNA: |
hsa-miR-92 |
| Disease: |
colorectal cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: in vitro inhibition of two miRNAs highly expressed in tumor tissue, miR-20a and miR-92, did not affect cell viability. This was unexpected, considering that these miRNAs are part of the miR-17-92 cluster reported to be oncogenic in other cancer types. Although our data indicated that the viability
of colon cancer cell lines were unaffected by inhibition of miR-20a and miR-92, other cancer hall marks such as motility, invasion, and angiogenesis might have been influenced. |
Reference:
Diagnostic and prognostic microRNAs in stage II colon cancer. | PMID:18676867
Schepeler T, Reinert JT, Ostenfeld MS, Christensen LL, Silahtaroglu AN, Dyrskj?t L, Wiuf C, S?rensen FJ, Kruh?ffer M, Laurberg S, Kauppinen S, ?rntoft TF, Andersen CL.
Cancer Res. 2008 Aug 1;68(15):6416-24. |
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