Friday, Mar.29, 2024
miRNA:

hsa-miR-23a

Disease:

Acute Promyelocytic Leukemia (APL)

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

CXCL12,FLJ13158 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

the miR-210 and the miR-23a/24-2 are directly repressed by the PMLRARA oncogene in APL cells and are regulated by RARA/RXRA heterodimers in non APL cells.The miRNAs repressed by PML-RARA are also implicated in the control of crucial pathways linked to leukemogenesis.

 

 

Reference:

Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia. | PMID:18941112
Saumet A, Vetter G, Bouttier M, Portales-Casamar E
Blood. 2008 Oct 21. [Epub ahead of print]

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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