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Monday, Apr.29, 2024
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| miRNA: |
hsa-miR-425 |
| Disease: |
glioblastoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We examined the microRNA profiles of Glioblastoma stem (CD133+) and non-stem (CD133-) cell populations and found up-regulation of several miRs in the CD133- cells, including miR-451, miR-486, and miR-425, some of which may be involved in regulation of brain differentiation. |
Reference:
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. | PMID:18765229
Gal H, Pandi G, Kanner AA, Ram Z
Biochem Biophys Res Commun. 2008 Nov 7;376(1):86-90. Epub 2008 Aug 31. |
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