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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-222 |
| Disease: |
melanoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
c-KIT, p27(Kip1) |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The inhibition of miRNA-221 and -222, which are abnormally expressed in melanoma and favor the induction of the malignant phenotype by downregulating c-KIT receptor and p27Kip, might in the future represent an efficient treatment for translation into the clinical setting. |
Reference:
MicroRNA-221 and -222 pathway controls melanoma progression. | PMID:18983236
Felicetti F, Errico MC, Segnalini P, Mattia G, Carè A.
Expert Rev Anticancer Ther. 2008 Nov;8(11):1759-65. |
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