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Thursday, May.16, 2024
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miRNA: |
hsa-let-7b |
Disease: |
neurodegeneration |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
Lin28,Mtpn : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-342-3p, miR-320, let-7b, miR-328, miR-128, miR-139-5p and miR-146a were over 2.5 fold up-regulated and miR-338-3p and miR-337-3p over 2.5 fold down-regulated. Only one of these miRNAs, miR-128, has previously been shown to be de-regulated in neurodegenerative disease. De-regulation of a unique subset of miRNAs suggests a conserved, disease-specific pattern of differentially expressed miRNAs is associated with prion-induced neurodegeneration. |
Reference:
A miRNA signature of prion induced neurodegeneration. | PMID:18987751
Saba R, Goodman CD, Huzarewich RL, Robertson C, Booth SA.
PLoS ONE. 2008;3(11):e3652. Epub 2008 Nov 6. |
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