| miRNA: |
hsa-let-7g |
| Disease: |
non-small cell lung cancer (NSCLC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
KRAS |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: We have identified the first miRNA binding-site SNPthat alone can predict a significant increase in NSCLC risk in people with a moderate smoking history.The mechanism may be due to altered regulation of the KRAS oncogene and possibly cellular let-7 levels as well. we found that the levels of let-7a, b, d, and g were lower in patients with the variant allele compared with patients without the variant alleleThese findings give insight into a new paradigm and support the pursuit of 3'UTR sequencing for similar SNPs in all tumor-related genes to better understand their role in genetic cancer risk. |
Reference:
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. | PMID:18922928
Chin LJ, Ratner E, Leng S, Zhai R, Nallur S
Cancer Res. 2008 Oct 15;68(20):8535-40. |
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