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Thursday, Mar.28, 2024
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miRNA: |
hsa-miR-15a |
Disease: |
Polycystic liver disease |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
Cdc25A |
Validated targets of miRNA from TarBase: |
unknown : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Lee and colleagues provide data to support a novel mechanism for cystogenesis involving microRNA. They demonstrate that levels of the miRNA miR15a are decreased in livers of patients with autosomal recessive and autosomal dominant polycystic kidney disease (ARPKD and ADPKD, respectively) and congenital hepatic fibrosis as well as in the PKC rat model of ARPKD. This results in increased expression of the cell-cycle regulator Cdc25A, which is a direct target of miR15a, and increased cellular proliferation and cystogenesis in vitro. These findings suggest that other miRNAs may also participate in the molecular pathogenesis of cystic liver and kidney diseases. |
Reference:
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. | PMID:18949056
Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N.
J Clin Invest. 2008 Nov 3;118(11):3714-3724. Epub 2008 Oct 23. |
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