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Sunday, May.12, 2024
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| miRNA: |
hsa-miR-101 |
| Disease: |
Spinocerebellar ataxia 1 |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ATXN1 |
Validated targets of miRNA from TarBase: |
Enx-1,MYCN : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. Here we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enhanced the cytotoxicity of polyglutamine-expanded ATXN1 in human cells. We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to protein dosage. |
Reference:
miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. | PMID:18758459
Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY
Nat Neurosci. 2008 Oct;11(10):1137-9. Epub 2008 Aug 31. |
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