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Thursday, May.2, 2024
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| miRNA: |
hsa-miR-126 |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
IRS-1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: mir-126 is one of the miRNAs underexpressed in breast cancer cells. Flow cytometry analysis showed that mir-126 inhibited cell cycle progression from G1/G0 to S. Further studies revealed that mir-126 targeted IRS-1 at the translation level. Knocking down of IRS-1 suppresses cell growth in HEK293 and breast cancer cell MCF-7, which recapitulates the effects of mir-126. |
Reference:
The cell growth suppressor, mir-126, targets IRS-1. | PMID:18834857
Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D.
Biochem Biophys Res Commun. 2008 Dec 5;377(1):136-40. Epub 2008 Oct 1. |
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