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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-15b |
| Disease: |
glioma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
CCNE1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. |
Reference:
MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. | PMID:19135980
Xia H, Qi Y, Ng SS, Chen X
Biochem Biophys Res Commun. 2009 Mar 6;380(2):205-10. Epub 2009 Jan 9. |
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