hsa-miR-192

colorectal cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

CDKN1A/p21

Validated targets of miRNA from TarBase:

SIP1 : More...

Description:

Here, we used array hybridization to find that p53 induces two additional, mutually related clusters of microRNAs, leading to the up-regulation of miR-192, miR-194, and miR-215. The same microRNAs were detected at high levels in normal colon tissue but were severely reduced in many colon cancer samples. On the other hand, miR-192 and its cousin miR-215 can each contribute to enhanced CDKN1A/p21 levels, colony suppression, cell cycle arrest, and cell detachment from a solid support. These effects were partially dependent on the presence of wild-type p53. Antagonizing endogenous miR-192 attenuated 5-fluorouracil-induced accumulation of p21. Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest.

Reference:

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. | PMID:19074875
Braun CJ, Zhang X, Savelyeva I, Wolff S, Moll UM, Schepeler T, ?rntoft TF, Andersen CL, Dobbelstein M.
Cancer Res. 2008 Dec 15;68(24):10094-104.