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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-204 |
| Disease: |
cholangiocarcinoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
Mcl-1, BCL2 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: The exogenous expression of mir-320 or mir-204 could negatively regulate Mcl-1 or Bcl-2 expression and facilitate chemotherapeutic drug-triggered apoptosis. |
Reference:
The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma. | PMID:19070389
Chen L, Yan HX, Yang W, Hu L, Yu LX, Liu Q, Li L, Huang DD, Ding J, Shen F, Zhou WP, Wu MC, Wang HY.
J Hepatol. 2009 Feb;50(2):358-69. Epub 2008 Nov 21. |
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