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Thursday, May.16, 2024
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| miRNA: |
hsa-miR-138 |
| Disease: |
anaplastic thyroid carcinoma (ATC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
hTERT |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-138 was significantly downregulated in ATC cell lines in comparison with papillary thyroid carcinoma (PTC)(P<0.01).Overexpression of miR-138 induced a reduction in human telomerase reverse transcriptase (hTERT) protein expression. |
Reference:
Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines. | PMID:18201269
Mitomo S, Maesawa C, Ogasawara S, Iwaya T, Shibazaki M, Yashima-Abo A, Kotani K, Oikawa H, Sakurai E, Izutsu N, Kato K, Komatsu H, Ikeda K, Wakabayashi G, Masuda T.
Cancer Sci. 2008 Feb;99(2):280-6. Epub 2008 Jan 14. |
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