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Friday, May.10, 2024
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| miRNA: |
hsa-miR-221 |
| Disease: |
melanoma |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
c-KIT, p27(Kip1) |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: mir-221 can directly interact with c-kit 3'UTR and inhibit cKit protein translation. Observed inverse correlation of the c-kit and mir-221 expression in various melanocytic cells pointed to its involvement in regulation of cKit in melanoma. Moreover, a series of functional assays demonstrated that mir-221 could directly inhibit cKit, p27(Kip1) and, possibly, other pivotal proteins in melanoma. Collectively, the studies presented here indicate that mir-221 could be a novel therapeutic target for the treatment of cutaneous melanoma. They also suggest that regulation of expression and functional activity of identified up-regulated miRNAs should be further studied in the context of malignant melanoma. |
Reference:
MicroRNA-dependent regulation of cKit in cutaneous melanoma. | PMID:19126397
Igoucheva O, Alexeev V.
Biochem Biophys Res Commun. 2009 Feb 13;379(3):790-4. Epub 2009 Jan 4. |
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