| miRNA: |
hsa-miR-141 |
| Disease: |
gastric cancer (stomach cancer) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
Clock : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: MiR-141 was significantly down-regulated in 80% (28/35) of primary gastric cancer tissues compared with pair-matched adjacent non-tumor tissues (P < 0.01). The expression of miR-141 was also found to be substantially reduced in several human gastric cancer cell lines such as MGC-803, HGC-27, SGC-7901 and BGC-823 cells. Overexpression of miR-141 with its precursors significantly inhibited the proliferation of gastric cancer cells. CONCLUSIONS: These results suggest that miR-141 may be involved in the development of gastric cancer through its inhibitory effect on cell proliferation. |
Reference:
Down-regulation of miR-141 in gastric cancer and its involvement in cell growth. | PMID:19363643
Du Y, Xu Y, Ding L, Yao H, Yu H, Zhou T, Si J.
J Gastroenterol. 2009 Apr 11. [Epub ahead of print] |
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