| miRNA: |
hsa-miR-221 |
| Disease: |
head and neck squamous cell carcinoma (HNSCC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
KIT : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: an expression ratio of miR-221:miR-375 showed a high sensitivity (0.92) and specificity (0.93) for disease prediction.CONCLUSIONS: These data suggest that cultured tumor cell lines are inappropriate for microRNA biomarker identification and that the pattern of microRNA expression in primary head and neck tissues is reflective of disease status, with certain microRNAs exhibiting strong predictive potential. These results indicate that miR-221 and miR-375 should be evaluated further as diagnostic biomarkers because they may hold utility in defining broadly responsive prevention and treatment strategies for HNSCC. |
Reference:
Clin Cancer Res. 2009 Apr 15;15(8):2850-5. Epub 2009 Apr 7. | PMID:19351747
Avissar M, Christensen BC, Kelsey KT, Marsit CJ.
MicroRNA Expression Ratio Is Predictive of Head and Neck Squamous Cell Carcinoma. |
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