Description: miR-let-7c, miR-100, and miR-218 were significantly overexpressed by all localized high GS, pT3 PC in comparison with metastatic carcinoma. (35.065 vs. 0.996 P<0.001), (55.550 vs. 8.314, P=0.010), and (33.549 vs. 2.748, P=0.001), respectively. We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 beta3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies. |
Reference:
Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. | PMID:19372056
Leite KR, Sousa-Canavez JM, Reis ST, Tomiyama AH, Camara-Lopes LH, Sa?udo A,
Antunes AA, Srougi M.
Urol Oncol. 2009 Apr 15. [Epub ahead of print] |
