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Saturday, May.18, 2024
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| miRNA: |
hsa-miR-208 |
| Disease: |
cardiac hypertrophy |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
THRAP1 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: A cardiac-specific microRNA (miR-208) encoded by an intron of the aMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of bMHC in response to stress and hypothyroidism. |
Reference:
Control of stress-dependent cardiac growth and gene expression by a microRNA. | PMID:17379774
van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN.
Science. 2007 Apr 27;316(5824):575-9. Epub 2007 Mar 22. |
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