| miRNA: |
hsa-miR-100 |
| Disease: |
Oral Squamous Cell Carcinoma (OSCC) |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-125b and miR-100 are down-regulated in OSCC tumor and cell lines, and that transfecting cells with exogenous miR-125b and miR-100 significantly reduced cell proliferation and modified the expression of target and nontarget genes, including some that are overexpressed in radioresistant OSCC cells. In conclusion, the down-regulation of miR-125b and miR-100 in OSCC appears to play an important role in the development and/or progression of disease and may contribute to the loss of sensitivity to ionizing radiation. |
Reference:
Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. | PMID:19396866
Henson BJ, Bhattacharjee S, O'Dee DM, Feingold E, Gollin SM.
Genes Chromosomes Cancer. 2009 Jul;48(7):569-82. |
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