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Friday, May.3, 2024
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| miRNA: |
hsa-miR-125a |
| Disease: |
breast cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
ERBB2,ERBB3,Lin28 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer. |
Reference:
Germline mutation of microRNA-125a is associated with breast cancer. | PMID:19411564
Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P.
J Med Genet. 2009 May;46(5):358-60. |
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