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Saturday, Apr.20, 2024
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| miRNA: |
hsa-miR-127 |
| Disease: |
Burkitt lymphoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
BLIMP1, XBP1 |
Validated targets of miRNA from TarBase: |
BCL6,Rtl1/Peg11 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Here, we investigated the expression of specific miRNAs predicted to be involved in B cell differentiation and we found that hsa-miR-127 is differentially expressed between EBV-positive and EBV-negative BLs. In particular, it was strongly up-regulated only in EBV-positive BL samples, whereas EBV-negative cases showed levels of expression similar to normal controls, including microdissected GC cells.In addition, we found evidence that hsa-miR-127 is involved in B cell differentiation process through post transcriptional regulation of BLIMP1 and XBP1. The over-expression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B cell differentiation process. |
Reference:
B cell differentiation in EBV-positive Burkitt Lymphoma is impaired at post-transcriptional level by miRNA altered expression. | PMID:19530237
Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F
Int J Cancer. 2009 Jun 15. [Epub ahead of print]
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