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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-143 |
| Disease: |
T-cell leukemia |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
ERK5 |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: the transfection of Jurkat cells with mature miR-143 induced a significant growth suppression and enhancement of CH-11-induced apoptosis. On the contrary, an extracellular signal-regulated protein kinase 5 (ERK5), which was determined to be a target of miR-143 in colon cancer DLD-1 cells, was time-dependently down-regulated at the translational level after the treatment. During the apoptosis, the expression level of FasL was maintained and the level of nuclear-Foxo3a was increased in the early phase. These data suggest that the up-regulation of miR-143 could be related to the apoptosis in part by targeting ERK5, which leads to promotion of Foxo3a/FasL positive feedback loop. |
Reference:
Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells. | PMID:19464056
Akao Y, Nakagawa Y, Iio A, Naoe T.
Leuk Res. 2009 May 20. [Epub ahead of print] |
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