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Friday, May.17, 2024
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| miRNA: |
hsa-miR-196a |
| Disease: |
colorectal cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment, migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. |
Reference:
High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. | PMID:19418581
Schimanski CC, Frerichs K, Rahman F, Berger M, Lang H, Galle PR, Moehler M,
Gockel I.
World J Gastroenterol. 2009 May 7;15(17):2089-96. |
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