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Wednesday, Apr.24, 2024
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| miRNA: |
hsa-miR-203 |
| Disease: |
pancreatic ductal adenocarcinoma (PDAC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Significant correlations between elevated microRNA expression and overall survival were observed for miR-155 (RR=2.50; p=0.005), miR-203 (RR=2.21; p=0.017), miR-210 (RR=2.48; p=0.005) and miR-222 (RR=2.05; p=0.035). Furthermore, tumours from patients demonstrating elevated expression levels of all four microRNAs possessed a 6.2-fold increased risk of tumour-related death compared to patients whose tumours showed a lower expression of these microRNAs. INTERPRETATION: This study provides the first evidence for an oncogenic activity of miR-155, miR-203, miR-210 and miR-222 in the development of pancreatic cancer as has been reported for other tumour types. Furthermore, the putative target genes for these microRNAs suggest a complex signalling network that can affect PDAC tumourigenesis and tumour progression. |
Reference:
Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumours associates with poorer survival. | PMID:19551852
Greither T, Grochola L, Udelnow A, Lautenschl?ger C, Würl P, Taubert H.
Int J Cancer. 2009 Jun 23. [Epub ahead of print] |
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