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Friday, May.3, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
non-small cell lung cancer (NSCLC) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Detection of mir-21 expression produced 69.66% sensitivity and 100.00% specificity in diagnosis of lung cancer, as compared with 47.82% sensitivity and 100.00% specificity by sputum cytology. The measurement of altered miRNA expression in sputum could be a useful noninvasive approach for the diagnosis of lung cancer. |
Reference:
Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. | PMID:19446359
Xie Y, Todd NW, Liu Z, Zhan M, Fang H, Peng H, Alattar M, Deepak J, Stass SA,
Jiang F.
Lung Cancer. 2009 May 13. [Epub ahead of print] |
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