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Thursday, Apr.25, 2024
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| miRNA: |
hsa-miR-214 |
| Disease: |
adrenocortical carcinoma |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
microarray |
| Expression pattern of miRNA: |
down-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
unknown : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miR-184 and miR-503 showed significantly higher, whereas miR-511 and miR-214 significantly lower expression in ACCs than in other groups. Expression of miR-210 was significantly lower in cortisol-secreting adenomas than in ACCs. By calculating the difference between dCTmiR-511 and dCTmiR-503 (delta cycle threshold), ACCs could be distinguished from benign adenomas with high sensitivity and specificity. Pathway analysis revealed the possible involvement of G2/M checkpoint damage in ACC pathogenesis. To our knowledge, this is the first report describing miR expression patterns and pathway analysis in sporadic adrenocortical tumors. miR biomarkers may be helpful for the diagnosis of adrenocortical malignancy. This tissue specific target prediction approach may be used in other tumors too. |
Reference:
Integrative molecular-bioinformatics study of human adrenocortical tumors: microRNA, tissue specific target prediction and pathway analysis. | PMID:19546168
T?mb?l Z, Szabó P, Molnár V, Wiener Z, T?lgyesi G
Endocr Relat Cancer. 2009 Jun 22. [Epub ahead of print] |
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