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Thursday, Mar.28, 2024
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miRNA: |
hsa-miR-21 |
Disease: |
diffuse large B-cell lymphoma (DLBCL) |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Expression of miR-21 was an independent prognostic indicator in de novo DLBCL (p<0.05).Identified microRNAs(miR-155, miR-21 and miR-221) that were more highly expressed in ABC-type than GCB-type cell lines. These microRNAs were over-expressed in de novo DLBCL (n=35), transformed DLBCL
(n=14) and follicular center lymphoma cases (n=27) compared to normal B cells. |
Reference:
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. | PMID:17487835
Lawrie CH, Soneji S, Marafioti T, Cooper CD, Palazzo S, Paterson JC, Cattan H, Enver T, Mager R, Boultwood J, Wainscoat JS, Hatton CS.
Int J Cancer. 2007 Sep 1;121(5):1156-61. |
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