Thursday, Mar.28, 2024
miRNA:

hsa-miR-21

Disease:

diffuse large B-cell lymphoma (DLBCL)

Relationship type:

Unspecified

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Expression of miR-21 was an independent prognostic indicator in de novo DLBCL (p<0.05).Identified microRNAs(miR-155, miR-21 and miR-221) that were more highly expressed in ABC-type than GCB-type cell lines. These microRNAs were over-expressed in de novo DLBCL (n=35), transformed DLBCL (n=14) and follicular center lymphoma cases (n=27) compared to normal B cells.

 

 

Reference:

MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. | PMID:17487835
Lawrie CH, Soneji S, Marafioti T, Cooper CD, Palazzo S, Paterson JC, Cattan H, Enver T, Mager R, Boultwood J, Wainscoat JS, Hatton CS.
Int J Cancer. 2007 Sep 1;121(5):1156-61.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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