hsa-miR-16

prostate cancer

Relationship type:

Unspecified

Detection method for miRNA expression:

northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

unknown

Validated targets of miRNA from TarBase:

BCL2,CGI-38 : More...

Description:

Fifteen differentially expressed microRNAs were identified with concordant fold-changes by microarray and RT-qPCR analyses. Ten microRNAs (hsa-miR-16, hsa-miR-31, hsa-miR-125b, hsa-miR-145, hsa-miR-149, hsa-miR-181b, hsa-miR-184, hsa-miR-205, hsa-miR-221, hsa-miR-222) were down-regulated and five miRNAs (hsa-miR-96, hsa-miR-182, hsa-miR-182*, hsa-miR-183, hsa-375) were up-regulated. Expression of five microRNAs correlated with Gleason score or pathological tumour stage. Already two microRNAs classified up to 84% of malignant and non-malignant samples correctly. Expression of hsa-miR-96 was associated with cancer recurrence after radical prostatectomy and that prognostic information was confirmed by an independent tumour sample set from 79 patients. That was shown with hsa-miR-96 and the Gleason score as final variables in the Cox models build in the two patient sets investigated. Thus, differential microRNAs in prostate cancer are useful diagnostic and prognostic indicators. The presented study provides a solid basis for further functional analyses of miRNAs in prostate cancer.

Reference:

Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. | PMID:19676045
Schäfer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, Jentzmik F, Miller K, Lein M, Kristiansen G, Jung K.
Int J Cancer. 2009 Aug 12.