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Friday, May.3, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
lung cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: miRNAs (miR-155, miR-17-3p, miR-106a, miR-93, let-7a-2, miR-145, let-7b, and miR-21) were related to the adenocarcinoma patient's survival. Patients with high expression of either miR-155, miR-17-3p, miR-106a, miR-93, or miR-21 and low expression of either let-7a-2, let-7b, or miR-145 were found to have a significantly worse prognosis. |
Reference:
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. | PMID:16530703
Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC.
Cancer Cell. 2006 Mar;9(3):189-98. |
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