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Friday, Apr.26, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
pancreatic cancer |
Relationship type: |
Unspecified |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
unknown |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Although miR-21 expression did not correlate with tumor size, differentiation, nodal status, or T stage, strong miR-21 expression was predictive of poorer outcome compared to absent or faint/focal miR-21 expression in patients with node-negative disease (median 27.7 months vs. 15.2, p=0.037). Nodal status was also predictive of survival (p=0.029). MicroRNA-21 is significantly overexpressed in pancreatic cancers as detected by in situ hybridization. Its strong expression predicts limited survival in patients with node-negative disease and may be an important biologic marker for outcome. |
Reference:
MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. | PMID:18642050
Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M.
J Gastrointest Surg. 2008 Dec;12(12):2171-6. Epub 2008 Jul 19. |
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