|
|
|
Thursday, Mar.28, 2024
|
|
|
|
|
|
miRNA: |
hsa-miR-21 |
Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
BCL2 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Transfected breast cancer MCF-7 cells with anti-miR-21 oligonucleotides and found that anti-miR-21 suppressed both cell growth in vitro and tumor growth in the xenograft mouse model. |
Reference:
miR-21-mediated tumor growth. | PMID:17072344
Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY.
Oncogene. 2007 Apr 26;26(19):2799-803. Epub 2006 Oct 30. |
|
|
|
|
|
|