Thursday, Mar.28, 2024
miRNA:

hsa-miR-21

Disease:

breast cancer

Relationship type:

Causal

Detection method for miRNA expression:

Northern blot, qRT-PCR etc

Expression pattern of miRNA:

up-regulated

Validated targets of miRNA from the reference:

BCL2

Validated targets of miRNA from TarBase:

PTEN,TPM1 : More...

Predicted targets: MIRANDA, TARGETSCAN, PICTAR-VERT

 

Description:

Transfected breast cancer MCF-7 cells with anti-miR-21 oligonucleotides and found that anti-miR-21 suppressed both cell growth in vitro and tumor growth in the xenograft mouse model.

 

 

Reference:

miR-21-mediated tumor growth. | PMID:17072344
Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY.
Oncogene. 2007 Apr 26;26(19):2799-803. Epub 2006 Oct 30.

 

 
 
 
  miRBase
  Tarbase
  miRGen
  miRGator
  CCBB
  MicroRNA.org
  miRRim
  miRNAMap 2.0
 
 
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