hsa-miR-9

ovarian cancer (OC)

Relationship type:

Causal

Detection method for miRNA expression:

northern blot, qRT-PCR etc

down-regulated

Validated targets of miRNA from the reference:

NF-kappaB1

Validated targets of miRNA from TarBase:

unknown : More...

Description:

Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cell growth in vitro. Furthermore, the 3'-UTR of NF-kappaB1 mRNA is found to be regulated directly by miR-9, demonstrating that NF-kappaB1 is a functionally important target of miR-9 in ovarian cancer cells. When miR-9 is overexpressed in ovarian cancer cells, the mRNA and protein levels of NF-kappaB1 are both suppressed, whereas inhibition of miR-9 results in an increase in the NF-kappaB1 expression level. Ovarian cancer tissues display significantly low expression of miR-9 and a high level of NF-kappaB1 compared with normal tissues, indicating that regulation of NF-kappaB1 by miR-9 is an important mechanism for miR-9 to inhibit ovarian cancer proliferation.

Reference:

MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1. | PMID:19702828
Guo LM, Pu Y, Han Z, Liu T, Li YX, Liu M, Li X, Tang H.
FEBS J. 2009 Aug 21.