hsa-miR-9

hepatocellular carcinoma (HCC)

Relationship type:

Causal

Detection method for miRNA expression:

northern blot, qRT-PCR etc

up-regulated

Validated targets of miRNA from the reference:

E-cadherin

Validated targets of miRNA from TarBase:

unknown : More...

Description:

The molecular mechanisms of hepatocellular carcinoma (HCC) metastasis are still poorly understood. Recent evidence implies genetic determinants of cancer metastasis. Because gene expression signature significantly differs between primary metastasis-free HCC and primary HCC with intrahepatic metastases, miRNA expression in those primary HCC may change correspondingly. The 28 up-regulated miRNAs, part of the reported miRNA profiles of HCC, were compared in primary HCC with or without metastases. Only eight miRNAs were found to be significantly up-regulated in primary HCC with metastases while miR-9 had the highest hold change. miR-9 was highly expressed in SK-Hep-1 cell when compared with other hepatoma cell lines and downregulation of miR-9 reduced SK-Hep-1 cell invasion. E-cadherin, a tumor invasion suppressor in HCC, was found to be a putative gene target of miR-9. E-cadherin was up-regulated by miR-9 inhibitor. The findings suggest miR-9 could be involved in HCC metastasis.

Reference:

MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell. | PMID:19572217
Hao-Xiang T, Qian W, Lian-Zhou C, Xiao-Hui H, Jin-Song C, Xin-Hui F, Liang-Qi C, Xi-Ling C, Wen L, Long-Juan Z.
Med Oncol. 2009 Jul 2.