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Friday, May.3, 2024
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| miRNA: |
hsa-miR-21 |
| Disease: |
breast cancer |
Relationship type: |
Causal |
Detection method for miRNA expression: |
Northern blot, qRT-PCR etc |
| Expression pattern of miRNA: |
up-regulated |
Validated targets of miRNA from the reference: |
TPM1 |
Validated targets of miRNA from TarBase: |
PTEN,TPM1 : More... |
| Predicted targets: |
MIRANDA, TARGETSCAN, PICTAR-VERT |
Description: Down-regulation of TPM1 by mir-21 may explain, at least in part, why suppression of mir-21 can inhibit tumor growth, further supporting the notion that mir-21 functions as an oncogene. |
Reference:
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). | PMID:17363372
Zhu S, Si ML, Wu H, Mo YY.
J Biol Chem. 2007 May 11;282(19):14328-36. Epub 2007 Mar 15. |
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